49ers vs Seahawks – Week 1 Fantasy Football Preview

Christian McCaffrey returns from injury, Ricky Pearsall steps into WR1 duties, and Cooper Kupp looks to bounce back as Sam Darnold leads Seattle.

Sep 03, 2025

∙ Paid

Line: 49ers -2.5 | Total: 45.5

This NFC West opener is lined tightly, with the 49ers slight road favorites. The big storylines: McCaffrey’s long-awaited return from a lost 2024 season, Pearsall inheriting WR1 duties with Brandon Aiyuk out and Jauan Jennings questionable, and Cooper Kupp aiming to reassert himself alongside Jaxon Smith-Njigba in Seattle. Both defenses are physical, but there are plenty of fantasy pieces that can still shine here.

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